Premarin (Conjugated Estrogens)

PREMARIN (C.E.S:Conjugated Estrogens) is a female hormone and is usually given to women who no longer produce the proper amount. PREMARIN (C.E.S:Conjugated Estrogens) is used to reduce menopause symptoms (e.g., hot flashes, vaginal dryness), to prevent bone loss (osteoporosis) in people at high risk, or to treat certain cancers in men and women (e.g., certain types of metastatic breast cancer). PREMARIN (C.E.S:Conjugated Estrogens) may be used to treat other conditions as determined by your doctor. If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. There are several medicines (e.g., raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen therapy for osteoporosis. If you have other medical conditions as well, and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options. Estrogen-containing products should not be used to prevent heart disease.

PREMARIN side effects, that may go away during treatment, include dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, or breast tenderness. If PREMARIN side effects continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience PREMARIN side effects like mental/mood changes (e.g., severe depression, memory loss), calf pain/swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes (e.g., change in contact lens fit, loss of vision) breast lumps, swelling of hands or feet, changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding), unusual vaginal discharge/itching/odor, or yellowing of eyes or skin. PREMARIN side effects are unlikely but seek immediate medical attention if PREMARIN side effects occur. Symptoms of PREMARIN side effects include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other PREMARIN side effects not listed above, contact your doctor, nurse, or pharmacist. WARNING: PREMARIN side effects have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women with a uterus who receive estrogen-only hormone therapy. PREMARIN side effects may also increase the risk of cancer of the ovary or breast. Estrogen-containing products should not be used to prevent heart disease. Estrogen given in combination with another hormone (progestin) for replacement therapy can infrequently cause PREMARIN side effects like heart disease (e.g., heart attacks), stroke, serious blood clots (pulmonary embolism and deep venous thrombosis), dementia, and cancer of the breast. These risks appear to depend on the length of time this medicine is used and the amount of estrogen per dose. Therefore, this medicine should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious PREMARIN side effects from long-term treatment. Consult your doctor/pharmacist for details. If you use this medicine for an extended period, you should be evaluated at least once a year (see CAUTIONS section). This medicine is not effective in preventing or treating a tendency toward miscarriages nor the threat of miscarriage. This medicine must not be used during pregnancy because its use may result in PREMARIN side effects like birth defects or cancer later in the child's life (see CAUTIONS section). Some medicines or medical conditions may interact with this medicin and lead to PREMARIN side effects.INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOU DOSE OR CONDITION may be needed if you are taking corticosteroids (e.g., prednisone); hydantoins (e.g., phenytoin); warfarin; or any medicines that affect certain liver enzymes (CYP450-3A4), such as azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, macrolide antibiotics (e.g., clarithromycin, erythromycin), phenobarbital, rifamycins (e.g., rifampin), ritonavir, cimetidine, or St. John's wort. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other PREMARIN side effects including a family medical history (especially breast lumps/cancer), asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids, endometriosis), cholesterol/lipid problems, gallbladder disease, excessive weight gain, certain blood disorder (porphyria), any allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have undiagnosed abnormal vaginal bleeding, cancer (e.g., breast cancer - also see COMMON USES section), blood clots, liver disease, or active/recent stroke or heart attack.