PREMPRO (CONJUGATED ESTROGENS and MEDROXYPROGESTERON) is a combination of hormones (estrogen and progestin) used to treat menopausal symptoms (e.g., hot flashes, vaginal dryness). PREMPRO (CONJUGATED ESTROGENS and MEDROXYPROGESTERON) is also used to prevent bone loss (osteoporosis) in people at high risk. If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. There are several medicines (e.g. raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen/progestin HRT for osteoporosis. If you have other medical conditions as well and are prescribed estrogen/progestin HRT for more than one condition, consult your doctor about your PREMPRO (CONJUGATED ESTROGENS and MEDROXYPROGESTERON) treatment plan and its options.

PREMPRO side effects include dizziness, lightheadedness, headache, stomach upset, bloating, irritability, changes in sleep patterns, fatigue, nausea, weight changes, increased or decreased interest in sex, or breast tenderness. If PREMPRO side effects continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience PREMPRO side effects like mental or mood changes (e.g., severe depression, memory loss); calf pain or swelling; sudden severe headache; chest pain; trouble breathing; one-sided weakness; slurred speech; vision changes (e.g., change in contact lens fit, loss of vision); breast lumps; swelling of hands and feet; changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding); unusual vaginal discharge, itching, or odor; or yellowing of eyes or skin. PREMPRO side effects are unlikely, but seek immediate medical attention if PREMPRO side effects occur. Symptoms of PREMPRO side effects include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other PREMPRO side effects not listed above, contact your doctor, nurse, or pharmacist.