This medication is used with other treatments for certain problems with the intestines (ulcerative colitis). Using this medication as an enema allows it to work directly on the affected area as well as throughout the body. It does not cure this problem, but it may relieve pain and decrease the amount of diarrhea and bloody stools caused by swelling (inflammation). Hydrocortisone is an anti-inflammatory drug (corticosteroid hormone). It works by decreasing the body's natural defense response and decreasing inflammation.
Pain/discomfort in the rectal area, headache, dizziness, menstrual period changes (e.g., delayed/irregular/absent periods), trouble sleeping, increased sweating, acne, increased appetite, or unusual weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.